IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS

Idu and the Treatment of Herpes Simplex Keratitis.

5-IoDo-2'-DEOXYURIDINE (IDU) is an antimetabolite that acts by displacing thymidine from deoxyribonucleic acid (DNA). This results in inhibition of DNA synthesis, which particularly affects virus particles in the active replication of herpes simplex keratitis in rabbits (Kaufman, Nesburn, and Maloney, 1962; Perkins, Wood, Sears, Prusoff, and Welch, 1962). Following the report of effective treat...

Cryogenic Treatment of Herpes Simplex Keratitis.

DURING the early stage of our experiments on the use of low temperature for cataract extraction (Krwawicz, 1961, 1963), we had several opportunities of observing the effects of accidentally touching the cornea with the cryoextractor refrigerated to about -79°C. This accident proved to be quite harmless in all cases as no lasting effect on the clarity of the cornea could be seen after the tissue...

Epidemiology of Herpes Simplex Keratitis.

Considerable information has been accumulated concerning the herpes virus and its relationship to man, its natural host (Table VI). It is evident that to control the diseases produced, by the virus it is essential that some means be found not only to control the acute manifestations but also to eliminate the harbored virus from the readily available supply in the numerous ubiquitous carriers. A...

Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

In a rabbit model of herpes simplex corneal ulceration, 5% phosphonoacetic acid solution or ophthalmic ointment suppressed clinical disease and virus replication. The effect of 5% phosphonoacetic acid ointment was equivalent to that of 0.5% idoxuridine ointment in the treatment of this established herpetic eye infection.

Photodynamic inactivation in the treatment of experimental herpes simplex keratitis.